Article
BRCA1, BRCA2 and TP53 mutations in very early-onset breast cancer with associated risks to relatives.
European journal of cancer (Oxford, England : 1990) - 1 May 2006
Lalloo Fiona, Varley Jennifer, Moran Anthony, Ellis David, O'dair Lindsay, Pharoah Paul, Antoniou Antonis, Hartley Roger, Shenton Andrew, Seal Sheila, Bulman Barbara, Howell Anthony, Evans D Gareth R
Abstract excerpt
Pathological mutations in BRCA1, BRCA2 and TP53 are associated with an increased risk of breast cancer. This study evaluated mutation frequency of these genes in early-onset breast cancer patients, and correlated this with family history and determined relative risks to family members. Patients with breast adenocarcinoma diagnosed 30 years were ascertained between 1980 and 1997. Family history was established and...
Topics
- Adenocarcinoma
- Adult
- Breast Neoplasms
- Female
- Genes, BRCA1
- Genes, BRCA2
- Genes, p53
- Humans
- Middle Aged
- Mutation
- Pedigree
- Penetrance
- Risk Factors