Article
Drosophila E2F1 has context-specific pro- and antiapoptotic properties during development.
Developmental cell - 1 Oct 2005
Moon Nam-Sung, Frolov Maxim V, Kwon Eun-Jeong, Di Stefano Luisa, Dimova Dessislava K, Morris Erick J, Taylor-Harding Barbie, White Kristin, Dyson Nicholas J
Abstract excerpt
E2F transcription factors are generally believed to be positive regulators of apoptosis. In this study, we show that dE2F1 and dDP are important for the normal pattern of DNA damage-induced apoptosis in Drosophila wing discs. Unexpectedly, the role that E2F plays varies depending on the position of the cells within the disc. In irradiated wild-type discs, intervein cells show a high level of DNA damage-induced...
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