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Article

The effector caspases drICE and dcp-1 have partially overlapping functions in the apoptotic pathway in Drosophila.

Cell death and differentiation - 1 Oct 2006

Xu D, Wang Y, Willecke R, Chen Z, Ding T, Bergmann A

Abstract excerpt

Caspases are essential components of the apoptotic machinery in both vertebrates and invertebrates. Here, we report the isolation of a mutant allele of the Drosophila effector caspase drICE as a strong suppressor of hid- (head involution defective-) induced apoptosis. This mutant was used to determine the apoptotic role of drICE. Our data are consistent with an important function of drICE for developmental and...

Topics

Amino Acid Sequence
Animals
Apoptosis
Caspases
Drosophila
Drosophila Proteins
Epistasis, Genetic
Eye
Genes, Insect
Models, Biological
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phenotype

Sequence Homology, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 16645642
DOI: 10.1038/sj.cdd.4401920
PMCID: PMC2519037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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The effector caspases drICE and dcp-1 have partially overlapping functions in the apoptotic pathway in Drosophila.PMID 16645642Read ↗

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