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Article

The deubiquitinase emperor's thumb is a regulator of apoptosis in Drosophila.

Developmental biology - 1 May 2009

Ribaya Jeronimo P, Ranmuthu Madhuka, Copeland Jeff, Boyarskiy Sergey, Blair Adrienne P, Hay Bruce, Laski Frank A

Abstract excerpt

We have characterized the gene emperor's thumb (et) and showed that it is required for the regulation of apoptosis in Drosophila. Loss-of-function mutations in et result in apoptosis associated with a decrease in the concentration of DIAP1. Overexpression of one form of et inhibits apoptosis, consistent with et having an anti-apoptotic function; however, overexpression of a second form of et induces apoptosis,...

Topics

Amino Acid Sequence
Animals
Apoptosis
Apoptosis Regulatory Proteins
Drosophila
Drosophila Proteins
Endopeptidases
Genes, Insect
Models, Biological
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phylogeny

Protein Structure, Tertiary

Sequence Homology, Amino Acid

Ubiquitin-Protein Ligases

Source

Identifiers

PMID: 19217892
DOI: 10.1016/j.ydbio.2009.02.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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