Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The deubiquitinase emperor's thumb is a regulator of apoptosis in Drosophila.

Developmental biology - 1 May 2009

Ribaya Jeronimo P, Ranmuthu Madhuka, Copeland Jeff, Boyarskiy Sergey, Blair Adrienne P, Hay Bruce, Laski Frank A

Abstract excerpt

We have characterized the gene emperor's thumb (et) and showed that it is required for the regulation of apoptosis in Drosophila. Loss-of-function mutations in et result in apoptosis associated with a decrease in the concentration of DIAP1. Overexpression of one form of et inhibits apoptosis, consistent with et having an anti-apoptotic function; however, overexpression of a second form of et induces apoptosis,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Apoptosis Regulatory Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drosophila

Share to Drosophila Proteins

Share to Endopeptidases

Share to Genes, Insect

Share to Sequence Homology, Amino Acid

Share to Ubiquitin-Protein Ligases

Source

Identifiers

PMID: 19217892
DOI: 10.1016/j.ydbio.2009.02.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The deubiquitinase emperor's thumb is a regulator of apoptosis in Drosophila.PMID 19217892Read ↗

Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis.Semantic proximity Read ↗

Control of apoptosis by Drosophila DCAF12.Semantic proximity Read ↗

Drosophila IAP1-mediated ubiquitylation controls activation of the initiator caspase DRONC independent of protein degradation.Semantic proximity Read ↗

Deubiquitinases: Modulators of Different Types of Regulated Cell DeathSemantic proximity Read ↗

Cleavage of the apoptosis inhibitor DIAP1 by the apical caspase DRONC in both normal and apoptotic Drosophila cells.Semantic proximity Read ↗

Systematic Analysis of the Physiological Importance of Deubiquitinating EnzymesSemantic proximity Read ↗

Inhibitor of apoptosis proteins in Drosophila: gatekeepers of deathSemantic proximity Read ↗

drICE is an essential caspase required for apoptotic activity in Drosophila cellsSemantic proximity Read ↗

Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery.Semantic proximity Read ↗

The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis inducers.Semantic proximity Read ↗

The effector caspases drICE and dcp-1 have partially overlapping functions in the apoptotic pathway in Drosophila.Semantic proximity Read ↗

The 19S Deubiquitinase Inhibitor b-AP15 Is Enriched in Cells and Elicits Rapid Commitment to Cell DeathSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.