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Article

The archipelago tumor suppressor gene limits rb/e2f-regulated apoptosis in developing Drosophila tissues.

Current biology : CB - 29 Sept 2009

Nicholson Sarah C, Gilbert M Melissa, Nicolay Brandon N, Frolov Maxim V, Moberg Kenneth H

Abstract excerpt

BACKGROUND: The Drosophila archipelago gene (ago) encodes the specificity component of a ubiquitin ligase that targets the cyclin E and dMyc proteins for degradation. Its human ortholog, Fbw7, is commonly lost in cancers, suggesting that failure to degrade ago/Fbw7 targets drives excess tissue gr...

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Identifiers

PMID: 19733076
DOI: 10.1016/j.cub.2009.07.068
PMCID: PMC2755617

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19733076-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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