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Article

Loss of dE2F compromises mitochondrial function.

Developmental cell - 25 Nov 2013

Ambrus Aaron M, Islam Abul B M M K, Holmes Katherine B, Moon Nam Sung, Lopez-Bigas Nuria, Benevolenskaya Elizaveta V, Frolov Maxim V

Abstract excerpt

E2F/DP transcription factors regulate cell proliferation and apoptosis. Here, we investigated the mechanism of the resistance of Drosophila dDP mutants to irradiation-induced apoptosis. Contrary to the prevailing view, this is not due to an inability to induce the apoptotic transcriptional program, because we show that this program is induced; rather, this is due to a mitochondrial dysfunction of dDP mutants. We...

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Identifiers

PMID: 24286825
DOI: 10.1016/j.devcel.2013.10.002
PMCID: PMC3866969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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