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Article

The pro-apoptotic activity of Drosophila Rbf1 involves dE2F2-dependent downregulation of diap1 and buffy mRNA.

Cell death & disease - 4 Sept 2014

Clavier A, Baillet A, Rincheval-Arnold A, Coléno-Costes A, Lasbleiz C, Mignotte B, Guénal I

Abstract excerpt

The retinoblastoma gene, rb, ensures at least its tumor suppressor function by inhibiting cell proliferation. Its role in apoptosis is more complex and less described than its role in cell cycle regulation. Rbf1, the Drosophila homolog of Rb, has been found to be pro-apoptotic in proliferative tissue. However, the way it induces apoptosis at the molecular level is still unknown. To decipher this mechanism, we...

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Identifiers

PMID: 25188515
DOI: 10.1038/cddis.2014.372
PMCID: PMC4540203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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