Article
A bidirectional kinesin motor in live Drosophila embryos.
Traffic (Copenhagen, Denmark) - 1 Nov 2005
Sciambi Catherine J, Komma Donald J, Sköld Helén Nilsson, Hirose Keiko, Endow Sharyn A
Abstract excerpt
Spindle assembly and elongation involve poleward and away-from-the-pole forces produced by microtubule dynamics and spindle-associated motors. Here, we show that a bidirectional Drosophila Kinesin-14 motor that moves either to the microtubule plus or minus end in vitro unexpectedly causes only minor spindle defects in vivo. However, spindles of mutant embryos are longer than wild type, consistent with increased...
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