Article
The Kinesin-14 tail: Dual microtubule binding domains drive spindle morphogenesis through tight microtubule cross-linking and robust sliding.
Molecular biology of the cell - 1 Jun 2025
Ems-McClung Stephanie C, Cassity MacKenzie, Prasannajith Anjaly, Walczak Claire E
Abstract excerpt
Proper spindle assembly requires the Kinesin-14 (K-14) family of motors to organize microtubules (MT) into the bipolar spindle by cross-linking and sliding antiparallel and parallel MTs through their motor and tail domains. How they mediate these different activities is unclear. We identified two MT-binding domains (MBD1 and MBD2) within the Xenopus K-14 XCTK2 tail and found that MBD1 MT affinity was weaker than...
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