Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The functional antagonism between Eg5 and dynein in spindle bipolarization is not compatible with a simple push-pull model.

Cell reports - 31 May 2012

Florian Stefan, Mayer Thomas U

Abstract excerpt

During cell division, the molecular motor Eg5 crosslinks overlapping antiparallel microtubules and pushes them apart to separate mitotic spindle poles. Dynein has been proposed as a direct antagonist of Eg5 at the spindle equator, pulling on antiparallel microtubules and favoring spindle collapse. Some of the experiments supporting this hypothesis relied on endpoint quantifications of spindle phenotypes rather...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Division
Share to Dyneins
Share to HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kinesins

Share to Microtubules

Share to Mitosis

Share to Models, Theoretical

Share to Spindle Apparatus

Source

Identifiers

PMID: 22832270
DOI: 10.1016/j.celrep.2012.03.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The functional antagonism between Eg5 and dynein in spindle bipolarization is not compatible with a simple push-pull model.PMID 22832270Read ↗

How Essential Kinesin-5 Becomes Non-Essential: Force Balance and Microtubule Dynamics MatterSemantic proximity Read ↗

How Essential Kinesin-5 Becomes Non-Essential in Fission Yeast: Force Balance and Microtubule Dynamics Matter.Semantic proximity Read ↗

Eg5 activity and density-driven bundling organize the human metaphase mitotic spindle independently of spindle bipolaritySemantic proximity Read ↗

Kinetochore dynein generates a poleward pulling force to facilitate congression and full chromosome alignment.Semantic proximity Read ↗

Opposing motors provide mechanical and functional robustness in the human spindleSemantic proximity Read ↗

A shift from kinesin 5-dependent metaphase spindle function during preimplantation development in mouseSemantic proximity Read ↗

Mechanisms for focusing mitotic spindle poles by minus end-directed motor proteins.Semantic proximity Read ↗

Two spatially distinct Kinesin-14 Pkl1 and Klp2 generate collaborative inward forces against Kinesin-5 Cut7 in <i>S. pombe</i>Semantic proximity Read ↗

A phenotypic screen identifies microtubule plus end assembly regulators that can function in mitotic spindle orientation.Semantic proximity Read ↗

XMAP215-EB1 interaction is required for proper spindle assembly and chromosome segregation in Xenopus egg extract.Semantic proximity Read ↗

Dynein-mediated pulling forces drive rapid mitotic spindle elongation in Ustilago maydis.Semantic proximity Read ↗

Force-transducing molecular ensembles at growing microtubule tips control mitotic spindle sizeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.