Article
Dynein motor regulation stabilizes interphase microtubule arrays and determines centrosome position.
The EMBO journal - 1 Dec 1999
Koonce M P, Köhler J, Neujahr R, Schwartz J M, Tikhonenko I, Gerisch G
Abstract excerpt
Cytoplasmic dynein is a microtubule-based motor protein responsible for vesicle movement and spindle orientation in eukaryotic cells. We show here that dynein also supports microtubule architecture and determines centrosome position in interphase cells. Overexpression of the motor domain in Dictyostelium leads to a collapse of the interphase microtubule array, forming loose bundles that often enwrap the nucleus....
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