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Article

PTPN2 but not PTPN22 is associated with Crohn's disease in a New Zealand population.

Tissue antigens - 1 Aug 2010

Morgan A R, Han D Y, Huebner C, Lam W J, Fraser A G, Ferguson L R

Abstract excerpt

Recent genome-wide association studies have provided evidence for the involvement of the genes PTPN2 and PTPN22 in the pathogenesis of Crohn's disease (CD). We investigated whether genetic variants in these genes were associated with CD in a New Zealand population. Single-nucleotide polymorphisms...

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Source

Identifiers

PMID: 20403149
DOI: 10.1111/j.1399-0039.2010.01493.x

Genes

PTPN2
PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20403149-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PTPN2 but not PTPN22 is associated with Crohn's disease in a New Zealand population.PMID 20403149Read ↗

PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background.Semantic proximity Read ↗

Differential association of two PTPN22 coding variants with Crohn’s disease and ulcerative colitisSemantic proximity Read ↗

Association between the PTPN2 gene and Crohn's disease: dissection of potential causal variants.Semantic proximity Read ↗

The first association study of Protein Tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) gene polymorphisms in Malaysian patients with Crohn's disease.Semantic proximity Read ↗

Genetic Variations of PTPN2 and PTPN22: Role in the Pathogenesis of Type 1 Diabetes and Crohn's Disease.Semantic proximity Read ↗

A case-control study of tyrosine phosphatase (PTPN22) confirms the lack of association with Crohn's disease.Semantic proximity Read ↗

The Clinical Relevance of the IBD-Associated Variation within the Risk Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 2 in Patients of the Swiss IBD Cohort.Semantic proximity Read ↗

Associations between PTPN2 polymorphisms and susceptibility to ulcerative colitis and Crohn's disease: a meta-analysis.Semantic proximity Read ↗

Genotype-Phenotype Associations of the CD-Associated Single Nucleotide Polymorphism within the Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 22 in Patients of the Swiss IBD Cohort.Semantic proximity Read ↗

PTPN2 is associated with Crohn's disease and its expression is regulated by NKX2-3.Semantic proximity Read ↗

Crohn's disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy.Semantic proximity Read ↗

Protein tyrosine phosphatase non-receptor type 2 and inflammatory bowel disease.Semantic proximity Read ↗

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