Article
A case-control study of tyrosine phosphatase (PTPN22) confirms the lack of association with Crohn's disease.
International journal of immunogenetics - 1 Oct 2005
Wagenleiter S E N, Klein W, Griga T, Schmiegel W, Epplen J T, Jagiello P
Abstract excerpt
In Crohn's disease (CD), the whole gastrointestinal tract can be affected by discontinuous and transmural inflammation. The terminal ileum and colon are especially prone to inflammation that comprises granulomata and later intestinal and perianal fistulas. Genome-wide linkage and epidemiological studies established genetic predisposition factors to CD. Recently, a variation of the intracellular protein tyrosine...
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