Article
The Clinical Relevance of the IBD-Associated Variation within the Risk Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 2 in Patients of the Swiss IBD Cohort.
Digestion - 1 Jan 2016
Spalinger Marianne R, Voegelin Marius, Biedermann Luc, Zeitz Jonas, Rossel Jean-Benoit, Sulz Michael Christian, Frei Pascal, Scharl Sylvie, Vavricka Stephan R, Fried Michael, Rogler Gerhard, Scharl Michael
Abstract excerpt
BACKGROUND/AIMS: The single nucleotide polymorphism (SNP) rs1893217 within the gene locus encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) results in a dysfunctional PTPN2 protein is associated with Crohn's disease (CD) and exists in perfect linkage disequilibrium with the CD- and ulcerative colitis (UC)-associated PTPN2 SNP rs2542151. We investigated associations of PTPN2 SNP rs1893217 and...
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