Differential association of two PTPN22 coding variants with Crohn's disease and ulcerative colitis.

doi:10.1002/ibd.21630

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Article

Differential association of two PTPN22 coding variants with Crohn's disease and ulcerative colitis.

Inflammatory bowel diseases - 1 Nov 2011

Diaz-Gallo Lina-Marcela, Espino-Paisán Laura, Fransen Karin, Gómez-García María, van Sommeren Suzanne, Cardeña Carlos, Rodrigo Luis, Mendoza Juan Luis, Taxonera Carlos, Nieto Antonio, Alcain Guillermo, Cueto Ignacio, López-Nevot Miguel A, Bottini Nunzio, Barclay Murray L, Crusius J Bart, van Bodegraven Adriaan A, Wijmenga Cisca, Ponsioen Cyriel Y, Gearry Richard B, Roberts Rebecca L, Weersma Rinse K, Urcelay Elena, Merriman Tony R, Alizadeh Behrooz Z, Martin Javier

Abstract excerpt

BACKGROUND: The PTPN22 gene is an important risk factor for human autoimmunity. The aim of this study was to evaluate for the first time the role of the R263Q PTPN22 polymorphism in ulcerative colitis (UC) and Crohn's disease (CD), and to reevaluate the association of the R620W PTPN22 polymorphism with both diseases. METHODS: A total of 1677 UC patients, 1903 CD patients, and 3111 healthy controls from an initial...

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PMID: 21287672
DOI: 10.1002/ibd.21630

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PTPN22

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Differential association of two PTPN22 coding variants with Crohn's disease and ulcerative colitis.PMID 21287672Read ↗

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