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Article

Lymphoid tyrosine phosphatase R620W variant and inflammatory bowel disease in Tunisia.

World journal of gastroenterology - 28 Jan 2010

Sfar Imen, Ben Aleya Walid, Mouelhi Leila, Aouadi Houda, Ben Rhomdhane Thouraya, Makhlouf Mouna, Ayed-Jendoubi Salwa, Gargaoui Houda, Najjar Taoufik, Ben Abdallah Taieb, Ayed Khaled, Gorgi Yousr

Abstract excerpt

AIM: To assess the possible association between PTPN22 (R620W) gene polymorphism and inflammatory bowel disease (IBD). METHODS: One hundred and sixty-four patients with IBD [105 Crohn's disease (CD) and 59 ulcerative colitis (UC)] and 100 healthy controls were recruited. Genotyping of the PTPN22...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20101775
DOI: 10.3748/wjg.v16.i4.479
PMCID: PMC2811802

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20101775-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Lymphoid tyrosine phosphatase R620W variant and inflammatory bowel disease in Tunisia.PMID 20101775Read ↗

The functional genetic variation in the PTPN22 gene has a negligible effect on the susceptibility to develop inflammatory bowel disease.Semantic proximity Read ↗

The R620W polymorphism of the protein tyrosine phosphatase 22 gene in autoimmune thyroid diseases and rheumatoid arthritis in the Tunisian population.Semantic proximity Read ↗

Differential association of two PTPN22 coding variants with Crohn's disease and ulcerative colitis.Semantic proximity Read ↗

The Clinical Relevance of the IBD-Associated Variation within the Risk Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 2 in Patients of the Swiss IBD Cohort.Semantic proximity Read ↗

PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background.Semantic proximity Read ↗

A case-control study of tyrosine phosphatase (PTPN22) confirms the lack of association with Crohn's disease.Semantic proximity Read ↗

Association of the PTPN22 R620W polymorphism with increased risk for SLE in the genetically homogeneous population of Crete.Semantic proximity Read ↗

Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue.Semantic proximity Read ↗

Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations.Semantic proximity Read ↗

The PTPN22 C1858T functional polymorphism and autoimmune diseases--a meta-analysis.Semantic proximity Read ↗

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The putative role of the C1858T polymorphism of protein tyrosine phosphatase PTPN22 gene in autoimmunity.Semantic proximity Read ↗

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