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Article

Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus.

Arthritis and rheumatism - 1 Jan 2005

Orozco Gisela, Sánchez Elena, González-Gay Miguel A, López-Nevot Miguel A, Torres Belén, Cáliz Rafael, Ortego-Centeno Norberto, Jiménez-Alonso Juan, Pascual-Salcedo Dora, Balsa Alejandro, de Pablo Rosario, Nuñez-Roldan Antonio, González-Escribano Maria Francisca, Martín Javier

Abstract excerpt

OBJECTIVE: To assess the possible association between the PTPN22 gene 1858C-->T polymorphism and the predisposition and clinical expression of 2 systemic autoimmune diseases, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). METHODS: Our study population consisted of 826 RA patients, 338 SLE patients, and 1,036 healthy subjects. All subjects were of Spanish Caucasian origin. Genotyping of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15641066
DOI: 10.1002/art.20771

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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