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Article

Differential association of the PTPN22 coding variant with autoimmune diseases in a Dutch population.

Genes and immunity - 1 Sept 2005

Zhernakova A, Eerligh P, Wijmenga C, Barrera P, Roep B O, Koeleman B P C

Abstract excerpt

Protein tyrosine phosphatase PTPN22 is involved in the negative regulation of T-cell responsiveness. Recently, the association of a coding variant of the PTPN22 gene-R620W(1858C>T) with a number of autoimmune diseases has been described. Therefore, we tested the association of PTPN22 1858*T allele in Dutch early onset type 1 diabetes (T1D) and rheumatoid arthritis (RA) patients, as well as celiac disease (CD)...

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Source

Identifiers

PMID: 15875058
DOI: 10.1038/sj.gene.6364220

Genes

PTPN22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Differential association of the PTPN22 coding variant with autoimmune diseases in a Dutch population.PMID 15875058Read ↗

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