Article
Human centromere protein B induces translational positioning of nucleosomes on alpha-satellite sequences.
The Journal of biological chemistry - 16 Dec 2005
Tanaka Yoshinori, Tachiwana Hiroaki, Yoda Kinya, Masumoto Hiroshi, Okazaki Tsuneko, Kurumizaka Hitoshi, Yokoyama Shigeyuki
Abstract excerpt
The human centromere proteins A (CENP-A) and B (CENP-B) are the fundamental centromere components of chromosomes. CENP-A is the centromere-specific histone H3 variant, and CENP-B specifically binds a 17-base pair sequence (the CENP-B box), which appears within every other alpha-satellite DNA repeat. In the present study, we demonstrated centromere-specific nucleosome formation in vitro with recombinant proteins,...
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