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Article

Motifs in the amino-terminus of CENP-A are required for its accumulation within the nucleus and at the centromere.

Oncotarget - 20 Jun 2017

Jing Ruiqi, Xi Jiajie, Leng Ye, Chen Wen, Wang Guiying, Jia Wenwen, Kang Jiuhong, Zhu Songcheng

Abstract excerpt

Centromere protein A (CENP-A) is a variant of core histone H3 that marks the centromere's location on the chromosome. The mechanisms that target the protein to the nucleus and the centromere have not been defined. In this study, we found that deletion of the first 53 but not the first 29 residues of CENP-A from the amino-terminus, resulted in its cytoplasmic localization. Two motifs, R42R43R44 and K49R52K53K56,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28489565
DOI: 10.18632/oncotarget.17204
PMCID: PMC5522188

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