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Article

Skeletal muscle phenotypes initiated by ectopic MyoD in transgenic mouse heart.

Development (Cambridge, England) - 1 Apr 1992

Miner J H, Miller J B, Wold B J

Abstract excerpt

Forced expression of the myogenic regulatory gene MyoD in many types of cultured cells initiates their conversion into skeletal muscle. It is not known, however, if MyoD expression serves to activate all or part of the skeletal muscle program in vivo during animal development, nor is it known how limiting the influences of cellular environment may be on the regulatory effects of MyoD. To begin to address these...

Topics

Animals
Cell Differentiation
Gene Expression
Genes
Genes, Regulator
Heart
Heart Defects, Congenital
Mice
Mice, Transgenic
Microscopy, Fluorescence
Morphogenesis
Muscles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1618148
DOI: 10.1242/dev.114.4.853

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1618148-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Skeletal muscle phenotypes initiated by ectopic MyoD in transgenic mouse heart.PMID 1618148Read ↗

Targeted inactivation of myogenic factor genes reveals their role during mouse myogenesis: a review.Semantic proximity Read ↗

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MyoD or Myf-5 is required for the formation of skeletal muscle.Semantic proximity Read ↗

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MyoD directly up-regulates premyogenic mesoderm factors during induction of skeletal myogenesis in stem cells.Semantic proximity Read ↗

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The core enhancer is essential for proper timing of MyoD activation in limb buds and branchial arches.Semantic proximity Read ↗

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