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Article

Targeted inactivation of myogenic factor genes reveals their role during mouse myogenesis: a review.

The International journal of developmental biology - 1 Feb 1996

Arnold H H, Braun T

Abstract excerpt

The role of the four myogenic regulating genes Myf-5, myogenin, MyoD, and MRF4 (herculin, Myf-6) during mouse embryogenesis has been investigated by targeted gene inactivation. Null mutations for the MyoD gene generate no skeletal muscle phenotype due to a compensatory activation of the Myf-5 gene. Mice carrying a homozygous Myf-5 mutation exert considerably delayed myotome formation with unexpected consequences....

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PMID: 8735947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted inactivation of myogenic factor genes reveals their role during mouse myogenesis: a review.PMID 8735947Read ↗

Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis.Semantic proximity Read ↗

Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice.Semantic proximity Read ↗

Two cell lineages, myf5 and myf5-independent, participate in mouse skeletal myogenesis.Semantic proximity Read ↗

MyoD or Myf-5 is required for the formation of skeletal muscle.Semantic proximity Read ↗

ES-cells carrying two inactivated myf-5 alleles form skeletal muscle cells: activation of an alternative myf-5-independent differentiation pathway.Semantic proximity Read ↗

Myogenin can substitute for Myf5 in promoting myogenesis but less efficiently.Semantic proximity Read ↗

Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene.Semantic proximity Read ↗

Myf-5 and myoD genes are activated in distinct mesenchymal stem cells and determine different skeletal muscle cell lineages.Semantic proximity Read ↗

Skeletal muscle phenotypes initiated by ectopic MyoD in transgenic mouse heart.Semantic proximity Read ↗

Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development.Semantic proximity Read ↗

Myogenin Regulates Exercise Capacity but Is Dispensable for Skeletal Muscle Regeneration in Adult mdx MiceSemantic proximity Read ↗

Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome.Semantic proximity Read ↗

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