Article
Targeted inactivation of myogenic factor genes reveals their role during mouse myogenesis: a review.
The International journal of developmental biology - 1 Feb 1996
Arnold H H, Braun T
Abstract excerpt
The role of the four myogenic regulating genes Myf-5, myogenin, MyoD, and MRF4 (herculin, Myf-6) during mouse embryogenesis has been investigated by targeted gene inactivation. Null mutations for the MyoD gene generate no skeletal muscle phenotype due to a compensatory activation of the Myf-5 gen...
Topics
- Animals
- DNA-Binding Proteins
- Gene Expression Regulation, Developmental
- Gene Targeting
- Homozygote
- Mice
- Mice, Knockout
- Muscle Proteins
- Muscle, Skeletal
- MyoD Protein
- Myogenic Regulatory Factor 5
- Myogenic Regulatory Factors
- Myogenin
- Phenotype
- Trans-Activators