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Article

MyoD directly up-regulates premyogenic mesoderm factors during induction of skeletal myogenesis in stem cells.

The Journal of biological chemistry - 28 Jan 2011

Gianakopoulos Peter J, Mehta Virja, Voronova Anastassia, Cao Yi, Yao Zizhen, Coutu Josée, Wang Xiaonan, Waddington Michelle S, Tapscott Stephen J, Skerjanc Ilona S

Abstract excerpt

Gain- and loss-of-function experiments have illustrated that the family of myogenic regulatory factors is necessary and sufficient for the formation of skeletal muscle. Furthermore, MyoD required cellular aggregation to induce myogenesis in P19 embryonal carcinoma stem cells. To determine the mechanism by which stem cells can be directed into skeletal muscle, a time course of P19 cell differentiation was examined...

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Identifiers

PMID: 21078671
DOI: 10.1074/jbc.M110.163709
PMCID: PMC3024746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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