The core enhancer is essential for proper timing of MyoD activation in limb buds and branchial arches.

doi:10.1016/j.ydbio.2003.09.018

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Article

The core enhancer is essential for proper timing of MyoD activation in limb buds and branchial arches.

Developmental biology - 15 Jan 2004

Chen Jennifer C J, Goldhamer David J

Abstract excerpt

Transgenic analyses have defined two transcriptional enhancers that regulate MyoD expression in mammals, the core enhancer and distal regulatory region; these enhancers exhibit complementary activities and together are sufficient to recapitulate MyoD expression in developing and mature skeletal muscle. The core enhancer is activated in presumptive muscle cells and determined myoblasts, suggesting an important...

Topics

Animals
Branchial Region
Chimera
Enhancer Elements, Genetic
Extremities
Gene Expression Regulation, Developmental
Genes, Reporter
In Situ Hybridization
Limb Buds
Mice
Mice, Transgenic
Mutation
MyoD Protein
Stem Cells

Source

Open in PubMed

Identifiers

PMID: 14732408
DOI: 10.1016/j.ydbio.2003.09.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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