Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Myf-5 and myoD genes are activated in distinct mesenchymal stem cells and determine different skeletal muscle cell lineages.

The EMBO journal - 15 Jan 1996

Braun T, Arnold H H

Abstract excerpt

Targeted inactivation of the myogenic determination genes myf-5 and myoD in mice resulted in moderate (Myf-5) or no muscle phenotypes (MyoD) and double knock-out mutants lacking both genes failed to develop any skeletal muscle. In order to determine the mechanism of this apparent genetic redundancy we investigated the basis of functional overlap between the two genes. Here we demonstrate that Myf-5 and MyoD are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Cell Differentiation
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Immunohistochemistry

Share to Phenotype

Share to Recombinant Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 8617206
PMCID: PMC449946

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myf-5 and myoD genes are activated in distinct mesenchymal stem cells and determine different skeletal muscle cell lineages.PMID 8617206Read ↗

ES-cells carrying two inactivated myf-5 alleles form skeletal muscle cells: activation of an alternative myf-5-independent differentiation pathway.Semantic proximity Read ↗

Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis.Semantic proximity Read ↗

MyoD or Myf-5 is required for the formation of skeletal muscle.Semantic proximity Read ↗

Two cell lineages, myf5 and myf5-independent, participate in mouse skeletal myogenesis.Semantic proximity Read ↗

Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice.Semantic proximity Read ↗

Targeted inactivation of myogenic factor genes reveals their role during mouse myogenesis: a review.Semantic proximity Read ↗

Redefining the genetic hierarchies controlling skeletal myogenesis: Pax-3 and Myf-5 act upstream of MyoD.Semantic proximity Read ↗

The multifaceted role of MyoD in adult skeletal muscle: homeostasis, regeneration, and diseasesSemantic proximity Read ↗

MyoD and Myf-5 define the specification of musculature of distinct embryonic origin.Semantic proximity Read ↗

Cultured myf5 null and myoD null muscle precursor cells display distinct growth defects.Semantic proximity Read ↗

Myogenin can substitute for Myf5 in promoting myogenesis but less efficiently.Semantic proximity Read ↗

Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.