Article
Myf-5 and myoD genes are activated in distinct mesenchymal stem cells and determine different skeletal muscle cell lineages.
The EMBO journal - 15 Jan 1996
Braun T, Arnold H H
Abstract excerpt
Targeted inactivation of the myogenic determination genes myf-5 and myoD in mice resulted in moderate (Myf-5) or no muscle phenotypes (MyoD) and double knock-out mutants lacking both genes failed to develop any skeletal muscle. In order to determine the mechanism of this apparent genetic redundan...
Topics
- Alleles
- Animals
- Cell Differentiation
- DNA-Binding Proteins
- Gene Expression Regulation
- Immunohistochemistry
- In Situ Hybridization
- Lac Operon
- Mesoderm
- Mice
- Microscopy, Immunoelectron
- Models, Biological