Article
Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene.
Nature - 5 Aug 1993
Hasty P, Bradley A, Morris J H, Edmondson D G, Venuti J M, Olson E N, Klein W H
Abstract excerpt
Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. To test myogenin's role in vivo, mice homozygous for a targeted mutation in the myogenin gene were generated. These mice survive fetal development but die immediately after...
Topics
- Animals
- Animals, Newborn
- Blotting, Northern
- Blotting, Western
- Embryonic and Fetal Development
- Female
- Genes, Lethal
- Male
- Mice
- Mice, Mutant Strains
- Muscle Proteins
- Muscles
- Mutagenesis
- MyoD Protein
- Myogenin
- Phenotype
- RNA, Messenger
- Trans-Activators