Article
Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene.
Nature - 5 Aug 1993
Hasty P, Bradley A, Morris J H, Edmondson D G, Venuti J M, Olson E N, Klein W H
Abstract excerpt
Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. To test myogenin's role in vivo, mice homozygous for a targeted mutation in the myogenin gene were generated. These mice survive fetal development but die immediately after birth and show a severe reduction of all skeletal muscle. Myogenin-mutant mice differ from mice carrying mutations in...
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