Article
Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development.
Cell - 30 Oct 1992
Rudnicki M A, Braun T, Hinuma S, Jaenisch R
Abstract excerpt
The myogenic basic HLH transcription factor family of genes, composed of MyoD, myogenin, Myf-5, and Myf-6, are thought to regulate skeletal muscle differentiation. To understand the role of MyoD in myogenesis, we have introduced a null mutation of MyoD into the germline of mice. Surprisingly, mic...
Topics
- Animals
- Cells, Cultured
- DNA-Binding Proteins
- Gene Expression Regulation
- Mice
- Muscle Proteins
- Muscles
- Mutagenesis, Site-Directed
- MyoD Protein
- Myogenic Regulatory Factor 5
- Phenotype
- RNA, Messenger
- Stem Cells
- Trans-Activators
- Up-Regulation