Article
MyoD or Myf-5 is required for the formation of skeletal muscle.
Cell - 31 Dec 1993
Rudnicki M A, Schnegelsberg P N, Stead R H, Braun T, Arnold H H, Jaenisch R
Abstract excerpt
Mice carrying null mutations in the myogenic regulatory factors Myf-5 or MyoD have apparently normal skeletal muscle. To address whether these two factors functionally substitute for one another in myogenesis, mice carrying mutant Myf-5 and MyoD genes were interbred. While mice lacking both MyoD and Myf-5 were born alive, they were immobile and died soon after birth. Northern blot and S1 nuclease analyses...
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