Article
Structure of PTB bound to RNA: specific binding and implications for splicing regulation.
Science (New York, N.Y.) - 23 Sept 2005
Oberstrass Florian C, Auweter Sigrid D, Erat Michèle, Hargous Yann, Henning Anke, Wenter Philipp, Reymond Luc, Amir-Ahmady Batoul, Pitsch Stefan, Black Douglas L, Allain Frédéric H-T
Abstract excerpt
The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA binding protein involved in multiple aspects of messenger RNA metabolism, including the repression of alternative exons. We have determined the solution structures of the four RNA binding domains (RBDs) of PTB, each bound to a CUCUCU oligonucleotide. Each RBD binds RNA with a different binding specificity. RBD3 and RBD4 interact, resulting in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.