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Article

Multisite RNA binding and release of polypyrimidine tract binding protein during the regulation of c-src neural-specific splicing.

Molecular cell - 1 Jun 2000

Chou M Y, Underwood J G, Nikolic J, Luu M H, Black D L

Abstract excerpt

We studied the role of polypyrimidine tract binding protein in repressing splicing of the c-src neuron-specific N1 exon. Immunodepletion/add-back experiments demonstrate that PTB is essential for splicing repression in HeLa extract. When splicing is repressed, PTB cross-links to intronic CUCUCU elements flanking the N1 exon. Mutation of the downstream CU elements causes dissociation of PTB from the intact...

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PMID: 10911989
DOI: 10.1016/s1097-2765(00)80260-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Multisite RNA binding and release of polypyrimidine tract binding protein during the regulation of c-src neural-specific splicing.PMID 10911989Read ↗

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