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Article

A transient α-helix in the N-terminal RNA recognition motif of polypyrimidine tract binding protein senses RNA secondary structure.

Nucleic acids research - 7 May 2020

Maris Christophe, Jayne Sandrine, Damberger Fred F, Beusch Irene, Dorn Georg, Ravindranathan Sapna, Allain Frédéric H-T

Abstract excerpt

The polypyrimidine tract binding protein (PTB) is a multi-domain protein involved in alternative splicing, mRNA localization, stabilization, polyadenylation and translation initiation from internal ribosome entry sites (IRES). In this latter process, PTB promotes viral translation by interacting extensively with complex structured regions in the 5'-untranslated regions of viral RNAs at pyrimidine-rich targets...

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Identifiers

PMID: 32170319
DOI: 10.1093/nar/gkaa155
PMCID: PMC7192611

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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