Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polypyrimidine tract-binding protein is essential for early mouse development and embryonic stem cell proliferation.

The FEBS journal - 1 Nov 2009

Shibayama Masaki, Ohno Satona, Osaka Takashi, Sakamoto Reiko, Tokunaga Akinori, Nakatake Yuhki, Sato Mitsuharu, Yoshida Nobuaki

Abstract excerpt

Polypyrimidine tract-binding protein (PTB) is a widely expressed RNA-binding protein with multiple roles in RNA processing, including the splicing of alternative exons, mRNA stability, mRNA localization, and internal ribosome entry site-dependent translation. Although it has been reported that increased expression of PTB is correlated with cancer cell growth, the role of PTB in mammalian development is still...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Blastocyst

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blotting, Northern

Share to Cell Cycle

Share to Embryo, Mammalian

Share to Embryonic Stem Cells

Share to Gene Expression Regulation, Developmental

Share to Polypyrimidine Tract-Binding Protein

Source

Identifiers

PMID: 19843185
DOI: 10.1111/j.1742-4658.2009.07380.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polypyrimidine tract-binding protein is essential for early mouse development and embryonic stem cell proliferation.PMID 19843185Read ↗

Cellular nucleic acid-binding protein is vital to testis development and spermatogenesis in miceSemantic proximity Read ↗

An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryosSemantic proximity Read ↗

Loss of nuclear poly(A)-binding protein 1 causes defects in myogenesis and mRNA biogenesisSemantic proximity Read ↗

Identification and characterization of human embryonic poly(A) binding protein (EPAB)Semantic proximity Read ↗

Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development.Semantic proximity Read ↗

Determination of functional domains in polypyrimidine-tract-binding protein.Semantic proximity Read ↗

Targeted disruption of one allele of the Y-box binding protein-1 (YB-1) gene in mouse embryonic stem cells and increased sensitivity to cisplatin and mitomycin C.Semantic proximity Read ↗

Ssrp1a controls organogenesis by promoting cell cycle progression and RNA synthesis.Semantic proximity Read ↗

ICln is essential for cellular and early embryonic viability.Semantic proximity Read ↗

RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genes.Semantic proximity Read ↗

BRCT domain-containing protein PTIP is essential for progression through mitosis.Semantic proximity Read ↗

An adenosine triphosphatase of the sucrose nonfermenting 2 family, androgen receptor-interacting protein 4, is essential for mouse embryonic development and cell proliferation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.