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Article

Structural insights to how mammalian capping enzyme reads the CTD code.

Molecular cell - 22 Jul 2011

Ghosh Agnidipta, Shuman Stewart, Lima Christopher D

Abstract excerpt

Physical interaction between the phosphorylated RNA polymerase II carboxyl-terminal domain (CTD) and cellular capping enzymes is required for efficient formation of the 5' mRNA cap, the first modification of nascent mRNA. Here, we report the crystal structure of the RNA guanylyltransferase component of mammalian capping enzyme (Mce) bound to a CTD phosphopeptide. The CTD adopts an extended β-like conformation...

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Identifiers

PMID: 21683636
DOI: 10.1016/j.molcel.2011.06.001
PMCID: PMC3142331

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