Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Susceptibility to colon carcinogenesis in C3H<-->C57BL/6 chimeric mice reflects both tissue microenvironment and genotype.

Cancer letters - 8 Aug 2006

Tsukamoto Tetsuya, Yamamoto Masami, Fukami Hiroko, Yoshikawa Akemi, Sakai Hiroki, Hirata Akihiro, Kusakabe Moriaki, Tatematsu Masae

Abstract excerpt

Considerable rodent strain differences have been documented with regard to susceptibility to colon carcinogens. To clarify mechanisms, chimeras of susceptible strain C3H and relatively resistant strain C57BL/6N (B6) mice were exposed to a colonotropic carcinogen, 1,2-dimethylhydrazine (DMH) and tumor incidence and multiplicity were assessed. In the chimeras, incidence was as high as the C3H level. Multiplicity of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chimera
Share to Colonic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Susceptibility

Share to Genotype

Share to Immunohistochemistry

Share to Mice, Inbred C3H

Share to Mice, Inbred C57BL

Source

Identifiers

PMID: 16168562
DOI: 10.1016/j.canlet.2005.08.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Susceptibility to colon carcinogenesis in C3H<-->C57BL/6 chimeric mice reflects both tissue microenvironment and genotype.PMID 16168562Read ↗

A locus that influences susceptibility to 1, 2-dimethylhydrazine-induced colon tumors maps to the distal end of mouse chromosome 3.Semantic proximity Read ↗

Mapping hyper-susceptibility to colitis-associated colorectal cancer in FVB/NJ mice.Semantic proximity Read ↗

Differences in susceptibility to colonic stem cell somatic mutation in three strains of mice.Semantic proximity Read ↗

Preliminary analysis of azoxymethane-induced colon tumorigenesis in mouse aggregation chimeras.Semantic proximity Read ↗

Azoxymethane-induced colon tumors and aberrant crypt foci in mice of different genetic susceptibility.Semantic proximity Read ↗

The potent colon carcinogen, 1,2-dimethylhydrazine induces mutations primarily in the colon.Semantic proximity Read ↗

Gene interaction and single gene effects in colon tumour susceptibility in mice.Semantic proximity Read ↗

Azoxymethane is a genetic background-dependent colorectal tumor initiator and promoter in mice: effects of dose, route, and diet.Semantic proximity Read ↗

Genetics of liver tumor susceptibility in mice.Semantic proximity Read ↗

Mouse strain susceptibility to diethylnitrosamine induced hepatocarcinogenesis is cell autonomous whereas sex-susceptibility Is due to the micro-environment: analysis with C3H <--> BALB / c sexually chimeric mice.Semantic proximity Read ↗

Identification of an X-linked locus modifying mouse skin tumor susceptibility.Semantic proximity Read ↗

C57BR/cdJ hepatocarcinogen susceptibility genes act cell-autonomously in C57BR/cdJ<-->C57BL/6J chimeras.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.