Article
Azoxymethane-induced colon tumors and aberrant crypt foci in mice of different genetic susceptibility.
Cancer letters - 14 Aug 1998
Papanikolaou A, Wang Q S, Delker D A, Rosenberg D W
Abstract excerpt
Azoxymethane (AOM) is an organotropic colon carcinogen that is commonly used to induce colon tumors in rodents. Unlike its parent compound, 1,2-dimethylhydrazine (DMH), a tumor susceptibility phenotype in inbred mice with respect to AOM has not been established. Thus, this study was undertaken to determine whether genetic susceptibility extends to this carcinogen. SWR/J, A/J (both susceptible to DMH...
Topics
- Animals
- Azoxymethane
- Carcinogens
- Colon
- Colonic Neoplasms
- Disease Susceptibility
- Male
- Mice
- Mice, Inbred A
- Mice, Inbred AKR
- Mice, Inbred Strains
- Phenotype