Article
Differences in susceptibility to colonic stem cell somatic mutation in three strains of mice.
The Journal of pathology - 1 Apr 2001
Kuraguchi M, Cook H, Williams E D, Thomas G A
Abstract excerpt
Different species and different strains of animals commonly show very different sensitivities to carcinogenic regimes, which are often unexplained. A major possible contributory factor is variation in susceptibility to mutation, but this has not been directly demonstrated. This study therefore quantified the colonic stem cell mutation frequency in three strains of mice using two carcinogens. Stem cell mutations...
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