Article
Identification of an X-linked locus modifying mouse skin tumor susceptibility.
Molecular carcinogenesis - 1 Nov 2005
George Kenneth, Iacobucci Audrey, Uitto Jessica, O'Brien Thomas G
Abstract excerpt
The enhancing effect of overexpression of an ornithine decarboxylase (Odc) transgene on skin tumor susceptibility can be modified by genetic loci present in several inbred mouse strains. The BALB/cJ strain is among the most resistant strains so far examined; tumor multiplicity following 7,12-dimethylbenz(a)anthracene (DMBA) treatment is reduced by 90% when the K6/ODC transgene is expressed on a BALB/cJ background...
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