Article
Azoxymethane is a genetic background-dependent colorectal tumor initiator and promoter in mice: effects of dose, route, and diet.
Toxicological sciences : an official journal of the Society of Toxicology - 1 Dec 2005
Bissahoyo Anika, Pearsall R Scott, Hanlon Kathleen, Amann Vicky, Hicks Donna, Godfrey Virginia L, Threadgill David W
Abstract excerpt
The azoxymethane (AOM) model has been widely used to investigate the pathology and genetics of colorectal cancer in rodents. However, there has been wide variation in treatment regimes, making it difficult to compare across studies. Consequently, standardizing AOM treatment and identifying source...
Topics
- Adenocarcinoma
- Animals
- Azoxymethane
- Carcinogens
- Colon
- Colorectal Neoplasms
- Crosses, Genetic
- Diet
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Drug Administration Routes
- Female
- Gene Expression Regulation, Neoplastic