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Article

Azoxymethane is a genetic background-dependent colorectal tumor initiator and promoter in mice: effects of dose, route, and diet.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Dec 2005

Bissahoyo Anika, Pearsall R Scott, Hanlon Kathleen, Amann Vicky, Hicks Donna, Godfrey Virginia L, Threadgill David W

Abstract excerpt

The azoxymethane (AOM) model has been widely used to investigate the pathology and genetics of colorectal cancer in rodents. However, there has been wide variation in treatment regimes, making it difficult to compare across studies. Consequently, standardizing AOM treatment and identifying sources of experimental variation would allow better comparisons across studies. In order to establish an optimal dosing...

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Identifiers

PMID: 16150884
DOI: 10.1093/toxsci/kfi313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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