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Article

The potent colon carcinogen, 1,2-dimethylhydrazine induces mutations primarily in the colon.

Mutation research - 14 Nov 2004

Newell Lórien E, Heddle John A

Abstract excerpt

1,2-Dimethylhydrazine (DMH) is a potent colon carcinogen that is commonly used as an initiator in studies of the effects of diet on colon cancer. Previous studies have shown that although this compound produces multiple tumors in the colons in most individuals of every species tested, it is, at best, marginally mutagenic in the bone marrow (micronuclei) and small intestine (Dlb-1 mutations). Here we report its...

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Identifiers

PMID: 15474405
DOI: 10.1016/j.mrgentox.2004.06.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The potent colon carcinogen, 1,2-dimethylhydrazine induces mutations primarily in the colon.PMID 15474405Read ↗

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