Article
Maternal expression of the checkpoint protein BubR1 is required for synchrony of syncytial nuclear divisions and polar body arrest in Drosophila melanogaster.
Development (Cambridge, England) - 1 Oct 2005
Pérez-Mongiovi Daniel, Malmanche Nicolas, Bousbaa Hassan, Sunkel Claudio
Abstract excerpt
The spindle checkpoint is a surveillance mechanism that regulates the metaphase-anaphase transition during somatic cell division through inhibition of the APC/C ensuring proper chromosome segregation. We show that the conserved spindle checkpoint protein BubR1 is required during early embryonic d...
Topics
- Alleles
- Animals
- Cell Cycle Proteins
- Cell Nucleus Division
- Centrosome
- Drosophila Proteins
- Drosophila melanogaster
- Female
- Gene Expression Regulation, Developmental
- Giant Cells
- Phenotype
- Spindle Apparatus