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Article

Maternal expression of the checkpoint protein BubR1 is required for synchrony of syncytial nuclear divisions and polar body arrest in Drosophila melanogaster.

Development (Cambridge, England) - 1 Oct 2005

Pérez-Mongiovi Daniel, Malmanche Nicolas, Bousbaa Hassan, Sunkel Claudio

Abstract excerpt

The spindle checkpoint is a surveillance mechanism that regulates the metaphase-anaphase transition during somatic cell division through inhibition of the APC/C ensuring proper chromosome segregation. We show that the conserved spindle checkpoint protein BubR1 is required during early embryonic development. BubR1 is maternally provided and localises to kinetochores from prophase to metaphase during syncytial...

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PMID: 16162651
DOI: 10.1242/dev.02028

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APC

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Maternal expression of the checkpoint protein BubR1 is required for synchrony of syncytial nuclear divisions and polar body arrest in Drosophila melanogaster.PMID 16162651Read ↗

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