Slippage of Mitotic Arrest and Enhanced Tumor Development in Mice with <b> <i>BubR1</i> </b> Haploinsufficiency

Abstract excerpt

A compromised spindle checkpoint is thought to play a key role in genetic instability that predisposes cells to malignant transformation. Loss of function mutations of BubR1, an important component of the spindle checkpoint, have been detected in human cancers. Here we show that BubR1(+/-) mouse embryonic fibroblasts are defective in spindle checkpoint activation, contain a significantly reduced amount of securin...