Article
Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila.
The Journal of cell biology - 12 Jul 1999
Basu J, Bousbaa H, Logarinho E, Li Z, Williams B C, Lopes C, Sunkel C E, Goldberg M L
Abstract excerpt
We have characterized the Drosophila mitotic checkpoint control protein Bub1 and obtained mutations in the bub1 gene. Drosophila Bub1 localizes strongly to the centromere/kinetochore of mitotic and meiotic chromosomes that have not yet reached the metaphase plate. Animals homozygous for P-element...
Topics
- Animals
- Apoptosis
- Brain
- Cell Cycle
- Chromosome Segregation
- Cloning, Molecular
- Drosophila melanogaster
- Epitopes
- Genes, Essential
- Genes, Insect
- Kinetochores
- Male
- Meiosis
- Mitosis
- Molecular Sequence Data
- Mutagenesis, Insertional