Article
The function of a spindle checkpoint gene bub-1 in C. elegans development.
PloS one - 15 Jun 2009
Wang Xiangming, Liu Min, Li Weida, Suh Christopher D, Zhu Zuoyan, Jin Yishi, Fan Qichang
Abstract excerpt
BACKGROUND: The serine/threonine kinase BUB1 (Budding Uninhibited by Benzimidazole 1) was originally identified in yeast as a checkpoint protein, based on its mutant's incapacity of delaying the cell cycle in response to loss of microtubules. Our understanding of its function is primarily from st...
Topics
- Animals
- Base Sequence
- Caenorhabditis elegans
- Cell Nucleus
- Crosses, Genetic
- Gene Expression Regulation, Developmental
- Genetic Complementation Test
- Models, Genetic
- Molecular Sequence Data
- Motor Neurons
- Mutation
- Phenotype
- Protein Serine-Threonine Kinases
- Sequence Homology, Nucleic Acid
- Spindle Apparatus