Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The function of a spindle checkpoint gene bub-1 in C. elegans development.

PloS one - 15 Jun 2009

Wang Xiangming, Liu Min, Li Weida, Suh Christopher D, Zhu Zuoyan, Jin Yishi, Fan Qichang

Abstract excerpt

BACKGROUND: The serine/threonine kinase BUB1 (Budding Uninhibited by Benzimidazole 1) was originally identified in yeast as a checkpoint protein, based on its mutant's incapacity of delaying the cell cycle in response to loss of microtubules. Our understanding of its function is primarily from studies carried out in yeast S. cerevisiae. It has been shown that it is a component of the mitotic spindle checkpoint...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Crosses, Genetic
Share to Genetic Complementation Test

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Models, Genetic

Share to Molecular Sequence Data

Share to Mutation

Share to Phenotype

Share to Sequence Homology, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 19526056
DOI: 10.1371/journal.pone.0005912
PMCID: PMC2691579

Genes

BUB1
APC
CDC20

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The function of a spindle checkpoint gene bub-1 in C. elegans development.PMID 19526056Read ↗

Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans.Semantic proximity Read ↗

Spindle assembly checkpoint genes reveal distinct as well as overlapping expression that implicates MDF-2/Mad2 in postembryonic seam cell proliferation in Caenorhabditis elegans.Semantic proximity Read ↗

BRC-1 acts in the inter-sister pathway of meiotic double-strand break repair.Semantic proximity Read ↗

Biallelic BUB1 mutations cause microcephaly, developmental delay, and variable effects on cohesion and chromosome segregation.Semantic proximity Read ↗

The Cdc20 homolog, FZY-1, and its interacting protein, IFY-1, are required for proper chromosome segregation in Caenorhabditis elegans.Semantic proximity Read ↗

Caenorhabditis elegans BUB-3 and SAN-1/MAD3 Spindle Assembly Checkpoint Components Are Required for Genome Stability in Response to Treatment with Ionizing Radiation.Semantic proximity Read ↗

Maternal expression of the checkpoint protein BubR1 is required for synchrony of syncytial nuclear divisions and polar body arrest in Drosophila melanogaster.Semantic proximity Read ↗

Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis.Semantic proximity Read ↗

Spindle assembly checkpoint regulates mitotic cell cycle progression during preimplantation embryo development.Semantic proximity Read ↗

Identification of the C. elegans anaphase promoting complex subunit Cdc26 by phenotypic profiling and functional rescue in yeast.Semantic proximity Read ↗

<i>Caenorhabditis elegans</i> germline development requires <i>brap-2</i>Semantic proximity Read ↗

Nearly complete deletion of BubR1 causes microcephaly through shortened mitosis and massive cell death.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.