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Mad2 is dispensable for accurate chromosome segregation but becomes essential when oocytes are subjected to environmental stress

15 Jul 2023

Abstract excerpt

Accurate chromosome segregation, monitored by the spindle assembly checkpoint (SAC), is crucial for the production of euploid cells. Previous in vitro studies by us and others showed that Mad2, a core member of the SAC, performs a checkpoint function in oocyte meiosis. Here, through an oocyte-specific knockout approach in mouse, we reconfirmed that Mad2-deficient oocytes exhibit an accelerated...

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PMID: 37485540
DOI: 10.1242/dev.201398

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