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Article

Mad1's ability to interact with Mad2 is essential to regulate and monitor meiotic synapsis in C. elegans.

PLoS genetics - 1 Nov 2021

Devigne Alice, Bhalla Needhi

Abstract excerpt

Meiotic homolog synapsis is essential to ensure accurate segregation of chromosomes during meiosis. In C. elegans, proper regulation of synapsis and a checkpoint that monitors synapsis relies on the spindle checkpoint components, Mad1 and Mad2, and Pairing Centers (PCs), cis-acting loci that interact with the nuclear envelope to mobilize chromosomes within the nucleus. Here, we test what specific functions of...

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Identifiers

PMID: 34762652
DOI: 10.1371/journal.pgen.1009598
PMCID: PMC8610272

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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