Article
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice.
Nature genetics - 1 Jul 2004
Baker Darren J, Jeganathan Karthik B, Cameron J Douglas, Thompson Michael, Juneja Subhash, Kopecka Alena, Kumar Rajiv, Jenkins Robert B, de Groen Piet C, Roche Patrick, van Deursen Jan M
Abstract excerpt
Faithful segregation of replicated chromosomes is essential for maintenance of genetic stability and seems to be monitored by several mitotic checkpoints. Various components of these checkpoints have been identified in mammals, but their physiological relevance is largely unknown. Here we show that mutant mice with low levels of the spindle assembly checkpoint protein BubR1 develop progressive aneuploidy along...
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