Article
Mosaic variegated aneuploidy in mouse BubR1 deficient embryos and pregnancy loss in human.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology - 1 Sept 2014
Schmid Michael, Steinlein Claus, Tian Qi, Hanlon Newell Amy E, Gessler Manfred, Olson Susan B, Rosenwald Andreas, Kneitz Burkhard, Fedorov Lev M
Abstract excerpt
Chromosome aberrations (aneuploidies mostly) are the cause of the majority of spontaneous abortions in humans. However, little is known about defects in the underlying molecular mechanisms resulting in chromosome aberrations and following failure of preimplantation embryo development, initiation...
Topics
- Aneuploidy
- Animals
- Cell Cycle Proteins
- Chromosome Banding
- Embryo Loss
- Embryo, Mammalian
- Female
- Gene Targeting
- Haploinsufficiency
- Humans
- Mice, Inbred C57BL
- Mice, Knockout
- Mitosis
- Mosaicism
- Phenotype