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Article

PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene.

Molecular and cellular biology - 1 Oct 1995

Hohaus S, Petrovick M S, Voso M T, Sun Z, Zhang D E, Tenen D G

Abstract excerpt

Growth factor receptors play an important role in hematopoiesis. In order to further understand the mechanisms directing the expression of these key regulators of hematopoiesis, we initiated a study investigating the transcription factors activating the expression of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha gene. Here, we demonstrate that the human GM-CSF receptor alpha...

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Identifiers

PMID: 7565736
DOI: 10.1128/MCB.15.10.5830
PMCID: PMC230835

Genes

EBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene.PMID 7565736Read ↗

Role of transcription factors C/EBPalpha and PU.1 in normal hematopoiesis and leukemia.Semantic proximity Read ↗

Granulocyte inducer C/EBPα inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisionsSemantic proximity Read ↗

Restriction of interferon gamma responsiveness and basal expression of the myeloid human Fc gamma R1b gene is mediated by a functional PU.1 site and a transcription initiator consensus.Semantic proximity Read ↗

PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors.Semantic proximity Read ↗

Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-BSemantic proximity Read ↗

Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1).Semantic proximity Read ↗

Identification of a Region Which Directs the Monocytic Activity of the Colony-Stimulating Factor 1 (Macrophage Colony-Stimulating Factor) Receptor Promoter and Binds PEBP2/CBF (AML1)Semantic proximity Read ↗

Positive and negative regulation of granulocyte-macrophage colony- stimulating factor promoter activity by AML1-related transcription factor, PEBP2Semantic proximity Read ↗

CCAAT/enhancer binding protein ɛ is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicingSemantic proximity Read ↗

The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter.Semantic proximity Read ↗

Role of Transcription Factors in Differentiation and Reprogramming of Hematopoietic CellsSemantic proximity Read ↗

Potential autoregulation of transcription factor PU.1 by an upstream regulatory element.Semantic proximity Read ↗

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