Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PU.1 is regulated by NF-kappaB through a novel binding site in a 17 kb upstream enhancer element.

Oncogene - 18 Feb 2010

Bonadies N, Neururer Ch, Steege A, Vallabhapurapu S, Pabst T, Mueller B U

Abstract excerpt

The majority of patients with acute myeloid leukemia (AML) still die of their disease, and novel therapeutic concepts are needed. Timely expression of the hematopoietic master regulator PU.1 is crucial for normal development of myeloid and lymphoid cells. Targeted disruption of an upstream regula...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CCAAT-Enhancer-Binding Protein-beta
Share to Chlorocebus aethiops
Share to COS Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Neutrophils

Share to NF-kappa B

Share to Protein Multimerization

Share to Protein Structure, Quaternary

Source

Identifiers

PMID: 19966852
DOI: 10.1038/onc.2009.371

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19966852-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PU.1 is regulated by NF-kappaB through a novel binding site in a 17 kb upstream enhancer element.PMID 19966852Read ↗

Core binding factor leukemia hijacks T-cell prone PU.1 antisense promoterSemantic proximity Read ↗

Heterozygous PU.1 mutations are associated with acute myeloid leukemia.Semantic proximity Read ↗

A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia.Semantic proximity Read ↗

Role of transcription factors C/EBPalpha and PU.1 in normal hematopoiesis and leukemia.Semantic proximity Read ↗

The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemiaSemantic proximity Read ↗

Heterozygous deletion of the PU.1 locus in human AML.Semantic proximity Read ↗

An integrated DNA interactome and transcriptome profiling reveals a PU.1/enhancer RNA-mediated Feed-forward Regulatory Loop Regulating monocyte/macrophage development and innate immune functionsSemantic proximity Read ↗

PU.1 downregulation in murine radiation-induced acute myeloid leukaemia (AML): from molecular mechanism to human AMLSemantic proximity Read ↗

The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells.Semantic proximity Read ↗

Down-regulation of PU.1 by Methylation of Distal Regulatory Elements and the Promoter Is Required for Myeloma Cell GrowthSemantic proximity Read ↗

PU.1-Dependent Enhancer Inhibition Separates Tet2 -Deficient Hematopoiesis from Malignant TransformationSemantic proximity Read ↗

Runx1 regulation of Pu.1 corepressor/coactivator exchange identifies specific molecular targets for leukemia differentiation therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.