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Article

Impaired repressor activity and biological functions of PU.1 in MEL cells induced by mutations in the acetylation motifs within the ETS domain.

Biochemical and biophysical research communications - 23 Sept 2005

Kihara-Negishi Fumiko, Suzuki Mitsuhiro, Yamada Toshiyuki, Sakurai Takuya, Oikawa Tsuneyuki

Abstract excerpt

PU.1, a hematopoietic Ets transcription factor, is required for development of the lymphoid and myeloid lineages. We have previously shown that PU.1 functions as both a transcriptional activator and repressor through complex formation with CBP/p300 and HDAC1/mSin3A/MeCP2, respectively. To determi...

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Source

Identifiers

PMID: 16098914
DOI: 10.1016/j.bbrc.2005.07.098

Genes

HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16098914-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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